Inhibitory Effect of Oral Sorbent on Accumulation of Albumin-Bound Indoxyl Sulfate in Serum of Experimental Uremic Rats
| Autor: | Michihito Ise, Tomio Kodama, Kenji Maeda, Sugano M, Tomoko Yazawa, Yasuo Uehara, Toshimitsu Niwa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Indoles Sorbent Nitrogen medicine.medical_treatment Administration Oral Nephrectomy chemistry.chemical_compound Oral administration Internal medicine medicine Animals Inhibitory effect Chromatography High Pressure Liquid Serum Albumin Uremia Creatinine business.industry Albumin Oxides Rats Inbred Strains Creatine medicine.disease Carbon Rats Endocrinology chemistry Indoxyl Sulfate Hemodialysis business Indican |
| Zdroj: | Nephron. 57:84-88 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | Serum indoxyl sulfate, which is markedly accumulated in uremic patients, cannot be removed efficiently by hemodialysis due to its albumin binding. To determine if oral adsorbent (AST-120) can decrease its serum concentration in uremic state, oral adsorbent was administered to experimental nephrectomized uremic rats. Uremic rats fed with oral adsorbent showed a significantly lower serum concentration of indoxyl sulfate compared to control uremic rats, even when serum concentrations of urea nitrogen and creatinine were not significantly decreased in the uremic rats fed with oral adsorbent. Indoxyl sulfate was detected only at a lower concentration in bile as compared with the serum of uremic rats. These results suggest that oral adsorbent adsorbs indole, a precursor of indoxyl sulfate, in the intestine and prevents the accumulation of indoxyl sulfate in uremic rats. |
| Databáze: | OpenAIRE |
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