| Autor: |
Catalina Álvarez-Larrotta, Olga M. Agudelo, Kenneth Gavina, Stephanie K. Yanow, Jaime Carmona-Fonseca, E. Arango |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
The American journal of tropical medicine and hygiene. 107(5) |
| ISSN: |
1476-1645 |
| Popis: |
Passive immunity acquired through transplacental IgG transport is essential to protect infants against pathogens as childhood vaccination programs begins. Diarrhea caused by rotavirus and neonatal tetanus are common and potentially fatal childhood infections that can be prevented by transplacental IgG. However, it is not known whether maternal infections in pregnancy can reduce the transfer of these antibodies to the fetus. This study evaluated the effect of submicroscopic Plasmodium infection during pregnancy on the transfer of maternal IgG antibodies against rotavirus (anti-RV) and tetanus toxoid (anti-TT) to newborns of pregnant women residing in Puerto Libertador and Tierralta, Colombia. Expression of different immune mediators and levels of IgG against rotavirus and tetanus toxoid were quantified in pregnant women with and without Plasmodium infection during pregnancy. Submicroscopic infection at the time of delivery was associated with a cord-to-maternal ratio (CMR) > 1 for anti-RV and 1 for anti-RV and Plasmodium vivax infections at delivery. The impact of Plasmodium infections on neonatal susceptibility to other infections warrants further exploration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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