Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex
| Autor: | Zhao-Lu Li, Xin-Jun Zhang, Wenying Angela Liu, Khadeejah T. Sultan, Zhongfu Shen, Owen Dean, Zhizhong Li, Song-Hai Shi, Jian Ma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell division Neurogenesis Science Thyroid Nuclear Factor 1 General Physics and Astronomy Cell Cycle Proteins Neocortex Biology Chandelier Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Neural Stem Cells Interneurons Cell polarity Asymmetric cell division medicine 10. No inequality lcsh:Science Adaptor Proteins Signal Transducing Multidisciplinary Staining and Labeling Asymmetric Cell Division Median Eminence General Chemistry Preoptic Area Embryonic stem cell 030104 developmental biology medicine.anatomical_structure nervous system GABAergic lcsh:Q Cell Adhesion Molecules Neuroglia Neuroscience Cell Division |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-07055-7 |
| Popis: | Diverse γ-aminobutyric acid (GABA)-ergic interneurons provide different modes of inhibition to support circuit operation in the neocortex. However, the cellular and molecular mechanisms underlying the systematic generation of assorted neocortical interneurons remain largely unclear. Here we show that NKX2.1-expressing radial glial progenitors (RGPs) in the mouse embryonic ventral telencephalon divide progressively to generate distinct groups of interneurons, which occupy the neocortex in a time-dependent, early inside-out and late outside-in, manner. Notably, the late-born chandelier cells, one of the morphologically and physiologically highly distinguishable GABAergic interneurons, arise reliably from continuously dividing RGPs that produce non-chandelier cells initially. Selective removal of Partition defective 3, an evolutionarily conserved cell polarity protein, impairs RGP asymmetric cell division, resulting in premature depletion of RGPs towards the late embryonic stages and a consequent loss of chandelier cells. These results suggest that consecutive asymmetric divisions of multipotent RGPs generate diverse neocortical interneurons in a progressive manner. Diverse GABAergic neurons arise from progenitors in the medial ganglionic eminence. Here, the authors show these progenitors are progressively fate-restricted, with early-born interneurons occupying cortex in an “inside-out” pattern and later-born types like chandelier cells generated “outside-in”. |
| Databáze: | OpenAIRE |
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