Influence of Variation in the Follicle-Stimulating Hormone Receptor Gene (FSHR) and Age at Menopause on the Development of Alzheimer’s Disease in Women
| Autor: | Renato Scacchi, Rosa Maria Corbo, Giuseppe Gambina, Elisabetta Broggio |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience media_common.quotation_subject Fertility Disease Neuropsychological Tests Biology Lower risk Apolipoproteins E Cognition Gene Frequency Alzheimer Disease Internal medicine Genotype medicine Humans Age of Onset Allele frequency Alleles Aged media_common Age Factors DNA Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Logistic Models Endocrinology Haplotypes Hormone receptor Receptors FSH Population study Female Menopause Geriatrics and Gerontology Age of onset |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 32:63-69 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000330472 |
| Popis: | Background: The higher prevalence of sporadic Alzheimer’s disease (AD) in women may be explained by their longer life expectancy, but also by biological gender-specific factors such as a woman’s past fertility. Methods: We investigated the relationship between fertility and susceptibility to AD in women by studying two polymorphisms at codons 307 and 680 of the follicle-stimulating hormone receptor gene (FSHR) involved in determining human fertility. The role of age at menopause (AM) as a gender-specific AD susceptibility determinant was also examined. The study population comprised 291 AD patients (70.1% women) and 134 controls (63.4% women). Results: Logistic regression analysis showed that only among the women the FSHR AS/AS genotype was associated with a significantly lower risk of AD (OR = 0.36, 95% CI: 0.15–0.85), suggesting a gender-specific protective role of the FSHR genotype against AD susceptibility. A lower age at natural menopause was observed in the AD patients (49.7 ± 2.53) than in the controls (50.7 ± 2.53, p = 0.02) and on linear regression analysis an association emerged between an earlier AM and an earlier AD onset (p = 0.004). Conclusions: Genetic and non-genetic gender-specific factors may contribute to the AD pathogenesis in women, although further investigations are required to clarify their actual role. |
| Databáze: | OpenAIRE |
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