Impaired Testicular Function in Patients With Carcinoma-In-Situ of the Testis
| Autor: | S W Hansen, Peter Meidahl Petersen, Aleksander Giwercman, Mikael Rørth, Jørgen G. Berthelsen, Gedske Daugaard, Niels E. Skakkebæk |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system Cancer Research medicine.medical_specialty Andrology Semen quality Follicle-stimulating hormone Testicular Neoplasms Internal medicine Testis Humans Medicine Testosterone Spermatogenesis Testicular cancer Sperm Count Leydig cell business.industry Carcinoma in situ Intratubular germ cell neoplasia Leydig Cells Luteinizing Hormone Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Oncology Sperm Motility Follicle Stimulating Hormone business Luteinizing hormone Orchiectomy Carcinoma in Situ |
| Zdroj: | Journal of Clinical Oncology. 17:173-173 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.1999.17.1.173 |
| Popis: | PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P 6/mL and 0.10 × 106, respectively) than in patients without (median, 9.1 × 106/mL and 32 × 106, respectively), whereas the levels of FSH were significantly higher (P CONCLUSION: Not only spermatogenesis but also Leydig cell function is impaired in testes with CIS. This impairment could be due to common factors in the pathogenesis of germ cell neoplasm and testicular dysfunction. Alternatively, CIS cells may have a negative impact on Leydig cell function. |
| Databáze: | OpenAIRE |
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