An oral Hemokine™, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo
| Autor: | Peter E. Newburger, P. Artur Plett, Stanley D. Kosanke, Christie M. Orschell, Michael S. Boosalis, Serguei A. Castaneda, Douglas V. Faller, Merriline Vedamony, Susan P. Perrine, Gary L. White, Daohong Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Myeloid Neutrophils Alpha (ethology) Biology Neutropenia Article Andrology 03 medical and health sciences Mice 0302 clinical medicine In vivo medicine Animals Myeloid Cells Progenitor cell Molecular Biology Phenylpropionates Cell Biology Hematology Recovery of Function Radiation Exposure medicine.disease Hematopoietic Stem Cells Survival Rate Haematopoiesis 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Molecular Medicine Erythropoiesis Stem cell Whole-Body Irradiation Papio |
| Popis: | An oral therapeutic which reduces duration of cytopenias and is active following accidental radiation exposures is an unmet need in radiation countermeasures. Alpha methylhydrocinnamate (ST7) prolongs STAT-5 phosphorylation, reduces growth-factor dependency of multi-lineage cell lines, and stimulates erythropoiesis. Here, ST7 and its isomers were studied for their effects on myeloid progenitors and hematopoietic stem cells (HSCs) following radiation, in nonhuman primates, and murine irradiation models. Addition of ST7 or ST7-S increased CFU-GM production by 1.7-fold (p200/mm3 and neutropenia recovered in 6 days with ST7 treatment and 18 days in controls (p |
| Databáze: | OpenAIRE |
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