Lactuca capensis reverses memory deficits in Aβ1-42-induced an animal model of Alzheimer's disease

Autor: Oana Cioanca, Mitica Ciorpac, Paula Alexandra Postu, Monica Hancianu, Marius Mihasan, Jaurès A. K. Noumedem, Brindusa Alina Petre, Dragos Lucian Gorgan, Lucian Hritcu
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
antioxidant
Interleukin-1beta
Gene Dosage
Hippocampus
IL‐1β
Apoptosis
Pharmacology
Asteraceae
Protein Carbonylation
chemistry.chemical_compound
0302 clinical medicine
Neurotrophic factors
Malondialdehyde
Spatial Memory
brain‐derived neurotrophic factor
amyloid
Lactuca capensis extract
Acetylcholinesterase
Glutathione
Anesthesia
Molecular Medicine
Original Article
Alzheimer's disease
DNA Fragmentation
Biology
03 medical and health sciences
Alzheimer Disease
medicine
Animals
RNA
Messenger
Rats
Wistar
Maze Learning
Cholinesterase
Brain-derived neurotrophic factor
Glutathione Peroxidase
Memory Disorders
Radial arm maze
Amyloid beta-Peptides
Plant Extracts
Superoxide Dismutase
Brain-Derived Neurotrophic Factor
Methanol
Cell Biology
Original Articles
medicine.disease
Peptide Fragments
Plant Leaves
Disease Models
Animal
030104 developmental biology
chemistry
biology.protein
Cholinergic
Cholinesterase Inhibitors
030217 neurology & neurosurgery
dementia
Zdroj: Journal of Cellular and Molecular Medicine
ISSN: 1582-4934
Popis: We investigated the neuropharmacological effects of the methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease (AD) rat model produced by direct intraventricular delivery of amyloid‐β1‐42 (Aβ1‐42). Behavioural assays such as Y‐maze and radial arm maze test were used for assessing memory performance. Aβ1‐42 decreased cognitive performance in the behavioural tests which were ameliorated by pre‐treatment with the methanolic extract. Acetylcholinesterase activity and oxidant–antioxidant balance in the rat hippocampus were abnormally altered by Aβ1‐42 treatment while these deficits were recovered by pre‐treatment with the methanolic extract. In addition, rats were given Aβ1‐42 exhibited in the hippocampus decreased brain‐derived neurotrophic factor (BDNF) mRNA copy number and increased IL‐1β mRNA copy number which was reversed by the methanolic extract administration. These findings suggest that the methanolic extract could be a potent neuropharmacological agent against dementia via modulating cholinergic activity, increasing of BDNF levels and promoting antioxidant action in the rat hippocampus.
Databáze: OpenAIRE
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