Antioxidative Effect ofAster yomena(Kitm.) Extract on C6Glioma Cell Line Damaged by AlCl3, Dementia Inducer
| Autor: | Young-Mi Seo |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Korean Journal of Clinical Laboratory Science, Vol 52, Iss 4, Pp 408-416 (2020) |
| ISSN: | 2288-1662 1738-3544 |
| DOI: | 10.15324/kjcls.2020.52.4.408 |
| Popis: | This study examined the neuronal cytotoxicity of aluminum chloride (AlCl3), a dementia inducer, and the protective effects of Aster yomena (Kitam.)(AY) extract on AlCl3-induced cytotoxicity in cultured C6 glioma cells. The antioxidative effects, such as the inhibitory ability of xanthine oxidase (XO) and superoxide anion-radical (SAR) scavenging ability, on cell viability were examined. AlCl3 decreased the cell viability significantly in a dose-dependent manner, and the XTT50 value was 130.0 μM in these cultures. The cytotoxicity of AlCl3 was determined to be mid-toxic according to the Borenfreund and Puerner’ toxic criteria. Quercetin (QU), an antioxidant, increased the cell viability reduced by AlCl3-induced cytotoxicity. The protective effect of the AY extract on AlCl3-induced cytotoxicity was analyzed. The AY extract increased the cell viability remarkably compared to the AlCl3-treated group and showed the inhibitory ability of XO and SAR-scavenging ability. The cytotoxicity of AlCl3 was correlated with oxidative stress, and the AY extract effectively prevented AlCl3-induced cytotoxicity through its antioxidative effects. In conclusion, natural resources, such as the AY extract, may be a putative agent for improving the cytotoxicity of heavy metallic compounds correlated with oxidative stress, such as AlCl3, a morbid agent. |
| Databáze: | OpenAIRE |
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