Separation of Cells and Microparticles in Insulator-Based Electrokinetic Systems
| Autor: | Alaleh Vaghef-Koodehi, Olivia D. Ernst, Blanca H. Lapizco-Encinas |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Analytical Chemistry. |
| ISSN: | 1520-6882 0003-2700 |
| Popis: | Presented here is the first continuous separation of microparticles and cells of similar characteristics employing linear and nonlinear electrokinetic phenomena in an insulator-based electrokinetic (iEK) system. By utilizing devices with insulating features, which distort the electric field distribution, it is possible to combine linear and nonlinear EK phenomena, resulting in highly effective separation schemes that leverage the new advancements in nonlinear electrophoresis. This work combines mathematical modeling and experimentation to separate four distinct binary mixtures of particles and cells. A computational model with COMSOL Multiphysics was used to predict the retention times ( |
| Databáze: | OpenAIRE |
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