Neuropsychological features of patients with Parkinson's disease and impulse control disorders
| Autor: | Eleonora Baldonero, Francesca De Nigris, Anna Rita Bentivoglio, Lucia Ricciardi, Antonio Daniele |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Impulsivity Parkinson's disease Poison control Disruptive Dermatology Audiology Impulse Control Neuropsychological Tests behavioral disciplines and activities cognitive functioning Cognition medicine Humans Psychiatry Dopamine dysregulation syndrome Aged Psychiatric Status Rating Scales Pathological gambling Impulse control disorders Disruptive Impulse Control and Conduct Disorders Female Middle Aged Parkinson Disease Psychomotor Performance Self Report Neurology (clinical) Psychiatry and Mental Health 2708 Medicine (all) and Conduct Disorders Neuropsychology General Medicine medicine.disease Iowa gambling task Settore MED/26 - NEUROLOGIA Frontal lobe Parkinson’s disease medicine.symptom Psychology Stroop effect |
| Popis: | Impulse control disorders (ICDs) are frequent in Parkinson's disease (PD). Aim of the present study was to investigate cognition and behaviour in PD patients with and without ICDs, in order to identify potential early clinical features which might be associated to the development of ICDs. We recruited 17 PD patients with ICDs and 17 without ICDs, matched for several clinical variables, without clinically significant cognitive deficits. Assessments included behavioural scales and a neuropsychological battery, including the Iowa Gambling Task (IGT). In patients with ICDs, the total score of the BIS and the Motor Impulsivity subscore were significantly higher than in patients without ICDs. In patients with ICDs, we observed only statistical trends towards a worse performance on neuropsychological tasks (go-no-go subtest of the Frontal Assessment Battery, oral verb naming task, copying of drawings with landmarks) sensitive to frontal lobe dysfunction (FLD) and on the IGT (loss of a greater amount of money, more risky choices). As compared to patients without ICDs, they reported a more than threefold number of errors on the interference subtest of Stroop test, which is also sensitive to FLD. Although this study did not show any significant difference between PD patients presenting ICDs as compared with patients without ICDs on neuropsychological variables, some preliminary evidence was detected suggesting a trend toward a worse performance of the PD-ICD group on few neuropsychological tasks which are at least partially sensitive to frontal lobe dysfunction, including tasks sensitive to dysfunction of ventral fronto-striatal loops. |
| Databáze: | OpenAIRE |
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