Circulating neuroactive C21- and C19-steroids in young men before and after ejaculation

Autor:	L, Stárka, M, Hill, H, Havlíková, L, Kancheva, V, Sobotka
Rok vydání:	2006
Předmět:	Adult Male Physiology Androstenedione Dehydroepiandrosterone Pregnanolone General Medicine 17-alpha-Hydroxypregnenolone Gas Chromatography-Mass Spectrometry Androgens Humans Ejaculation Testosterone Orgasm
Zdroj:	Physiological Research. :429-436
ISSN:	1802-9973 0862-8408
DOI:	10.33549/physiolres.930829
Popis:	Twelve neuroactive and neuroprotective steroids, androgens and androgen precursors i.e. 3alpha,17beta-dihydroxy-5alpha-androstane, 3alpha-hydroxy-5alpha-androstan-17-one, 3alpha-hydroxy-5beta-androstan-17-one, androst-5-ene-3beta,17beta-diol, 3beta,17alpha-dihydroxy-pregn-5-en-20-one (17alpha-hydroxy-pregnenolone), 3beta-hydroxy-androst-5-en-17-one (dehydroepiandrosterone, DHEA), testosterone, androst-4-ene-3,17-dione (androstenedione), 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone), 3beta-hydroxy-pregn-5-en-20-one (pregnenolone), 7alpha-hydroxy-DHEA, and 7beta-hydroxy-DHEA were measured using the GC-MS system in young men before and after ejaculation provoked by masturbation. The circulating level of 17alpha-hydroxypregnenolone increased significantly, whereas the other circulating steroids were not changed at all. This fact speaks against the hypothesis that a drop in the level of neuroactive steroids, e.g. allopregnanolone may trigger the orgasm-related increase of oxytocin, reported by other authors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5ce079dd9f88e2583ac66e0589f44b https://doi.org/10.33549/physiolres.930829 Zobrazit plný text záznamu