Optimal Method for Reporting Prostate Cancer Grade in MRI-targeted Biopsies
| Autor: | Leili Mirsadraei, Jonathan Melamed, Bogdan Isaila, Fang-Ming Deng, Yuhe Xia, Park Kyung, Qinghu Ren, Derek Jones, Deepthi Hoskoppal, Hongying Huang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Image-Guided Biopsy Male Concordance medicine.medical_treatment Magnetic Resonance Imaging Interventional Gleason grade Medical Records Pathology and Forensic Medicine Lesion Prostate cancer Predictive Value of Tests Biopsy medicine Humans Aged Retrospective Studies Aged 80 and over Prostatectomy medicine.diagnostic_test business.industry Prostatic Neoplasms Reproducibility of Results Cancer Magnetic resonance imaging Middle Aged medicine.disease Surgery Biopsy Large-Core Needle Neoplasm Grading Anatomy medicine.symptom business Nuclear medicine |
| Zdroj: | American Journal of Surgical Pathology. 46:44-50 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000001758 |
| Popis: | When multiple cores are biopsied from a single magnetic resonance imaging (MRI)-targeted lesion, Gleason grade may be assigned for each core separately or for all cores of the lesion in aggregate. Because of the potential for disparate grades, an optimal method for pathology reporting MRI lesion grade awaits validation. We examined our institutional experience on the concordance of biopsy grade with subsequent radical prostatectomy (RP) grade of targeted lesions when grade is determined on individual versus aggregate core basis. For 317 patients (with 367 lesions) who underwent MRI-targeted biopsy followed by RP, targeted lesion grade was assigned as (1) global Grade Group (GG), aggregated positive cores; (2) highest GG (highest grade in single biopsy core); and (3) largest volume GG (grade in the core with longest cancer linear length). The 3 biopsy grades were compared (equivalence, upgrade, or downgrade) with the final grade of the lesion in the RP, using κ and weighted κ coefficients. The biopsy global, highest, and largest GGs were the same as the final RP GG in 73%, 68%, 62% cases, respectively (weighted κ: 0.77, 0.79, and 0.71). For cases where the targeted lesion biopsy grade scores differed from each other when assigned by global, highest, and largest GG, the concordance with the targeted lesion RP GG was 69%, 52%, 31% for biopsy global, highest, and largest GGs tumors (weighted κ: 0.65, 0.68, 0.59). Overall, global, highest, and largest GG of the targeted biopsy show substantial agreement with RP-targeted lesion GG, however targeted global GG yields slightly better agreement than either targeted highest or largest GG. This becomes more apparent in nearly one third of cases when each of the 3 targeted lesion level biopsy scores differ. These results support the use of global (aggregate) GG for reporting of MRI lesion-targeted biopsies, while further validations are awaited. |
| Databáze: | OpenAIRE |
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