Arterial spin labeling brain MRI study to evaluate the impact of deafness on cerebral perfusion in 79 children before cochlear implantation
| Autor: | Eric Bizaguet, Ludovic Fillon, Volodia Dangouloff-Ros, Jennifer Boisgontier, Erea Noel Garabedian, Monica Zilbovicius, David Grevent, Caroline Rutten, N. Boddaert, Charles-Joris Roux, Ana Saitovitch, Natalie Loundon, Françoise Denoyelle, I. Rouillon, Hervé Lemaitre, Alice Vinçon-Leite, Raphael Levy, Arnaud Coez, Sandrine Marlin |
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| Přispěvatelé: | Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de correction auditive Eric Bizaguet, Institut de l'Audition [Paris] (IDA), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris (UP), INSERM U1299 'Trajectoires développementales et Psychiatrie', Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Paris Cité (UPCité), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité) |
| Rok vydání: | 2021 |
| Předmět: |
Arterial spin labeling
[SDV]Life Sciences [q-bio] medicine.medical_treatment Deafness Audiology Intelligibility (communication) lcsh:RC346-429 0302 clinical medicine Gyrus Cochlear implant Medicine Child Children 05 social sciences Brain Regular Article Cochlear Implantation Magnetic Resonance Imaging Brain development Perfusion Treatment Outcome medicine.anatomical_structure Neurology Cerebral blood flow Cerebrovascular Circulation Child Preschool Oral intelligibility scores Speech Perception lcsh:R858-859.7 medicine.symptom MRI medicine.medical_specialty Speech perception Hearing loss Cognitive Neuroscience Cochlear implant results lcsh:Computer applications to medicine. Medical informatics Auditory cortex 050105 experimental psychology 03 medical and health sciences otorhinolaryngologic diseases Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Cerebral perfusion pressure lcsh:Neurology. Diseases of the nervous system Retrospective Studies business.industry Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neuroimage-Clinical Neuroimage-Clinical, Elsevier, 2021, 29, pp.102510-. ⟨10.1016/j.nicl.2020.102510⟩ NeuroImage : Clinical Neuroimage-Clinical, 2021, 29, pp.102510-. ⟨10.1016/j.nicl.2020.102510⟩ NeuroImage: Clinical, Vol 29, Iss, Pp 102510-(2021) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2020.102510 |
| Popis: | Highlights • Arterial spin labeling brain MRI measure deafness impact on cerebral perfusion. • Deafness in childhood modifies the temporal perfusion evolution across age. • Cochlear implant pronostics is bad in case of high CBF values in occipital regions. • Cochlear implantation before 4 years old is required. Age at implantation is considered to be a major factor, influencing outcomes after pediatric cochlear implantation. In the absence of acoustic input, it has been proposed that cross-modal reorganization can be detrimental for adaptation to the new electrical input provided by a cochlear implant. Here, through a retrospective study, we aimed to investigate differences in cerebral blood flow (CBF) at rest prior to implantation in children with congenital deafness compared to normally hearing children. In addition, we looked at the putative link between pre-operative rest-CBF and the oral intelligibility scores at 12 months post-implantation. Finally, we observed the evolution of perfusion with age, within brain areas showing abnormal rest-CBF associated to deafness, in deaf children and in normally hearing children. In children older than 5 years old, results showed a significant bilateral hypoperfusion in temporal regions in deaf children, particularly in Heschl’s gyrus, and a significant hyperperfusion of occipital regions. Furthermore, in children older than 5 years old, whole brain voxel-by-voxel correlation analysis between pre-operative rest-CBF and oral intelligibility scores at 12 months post-implantation, showed significant negative correlation localized in the occipital regions: children who performed worse in the speech perception test one year after implantation were those presenting higher preoperative CBF values in these occipital regions. Finally, when comparing mean relative perfusion (extracted from the temporal regions found abnormal on whole-brain voxel-based analysis) across ages in patients and controls, we observed that the temporal perfusion evolution was significantly different in deaf children than in normally hearing children. Indeed, while temporal perfusion increased with age in normally hearing children, it remained stable in deaf children. We showed a critical period around 4 years old, where in the context of auditory deprivation, there is a lack of synaptic activity in auditory regions. These results support the benefits of early cochlear implantation to maximize the effectiveness of auditory rehabilitation and to avoid cross-modal reorganization. |
| Databáze: | OpenAIRE |
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