Carbopol-olive oil-based bigel drug delivery system of doxycycline hyclate for the treatment of acne
| Autor: | Poornima Agrawal, Vandana Soni, Avijit Kumar Bakshi, Vishal Gour, Indu Lata Kanwar, Kumud Soni, Tanweer Haider |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
business.industry Organic Chemistry Acrylic Resins Pharmaceutical Science Hydrogels medicine.disease Doxycycline Hyclate Drug Delivery Systems Doxycycline Drug Discovery Self-healing hydrogels Drug delivery Acne Vulgaris Medicine Effective treatment Animals Rabbits business Olive Oil Acne Olive oil |
| Zdroj: | Drug development and industrial pharmacy. 47(6) |
| ISSN: | 1520-5762 |
| Popis: | The objective of this study was to prepare and evaluate the doxycycline hyclate containing bigel for the effective treatment of acne.Bigels are biphasic systems formed by water-based hydrogels and oil-based organogel. Carbopol 940 was used to prepare the hydrogel phase, whereas Span-60 and olive oil for the oleogel phase.The microstructure of bigel confirmed the oil in water type emulsion formation. The average droplet size of formulations was found 15-50 µm, and a bell-shaped droplet distribution curve, rheological, or viscosity studies suggested that the consistency and stability of bigel decrease with high organogel concentration. Three formulations (F1, F2, and F3) of the different ratios of hydrogel:oleogel (60:40, 70:30, and 80:20) were prepared in which F1 was less stable compared to F2 and F3. The drug content of F2 and F3 was respectively 79.94 and 71.33%. Formulation F2 was found more effective as compared to F3 based on |
| Databáze: | OpenAIRE |
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