Co-existence of cutaneous T-cell lymphoma and B hairy cell leukemia
| Autor: | Maria Santacatterina, Rossella Paolini, Chiara Menin, Annarosa Del Mistro, Emma D'Andrea, Laura Bonaldi, Emilio Ramazzina, Alessandro Poletti, M. Montagna, Sergio Zamboni |
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| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Lymphocytosis Biopsy Immunophenotyping Bone Marrow hemic and lymphatic diseases Leukemia B-Cell medicine Humans Hairy cell leukemia Aged Skin Southern blot Leukemia Hairy Cell Mycosis fungoides medicine.diagnostic_test business.industry Cutaneous T-cell lymphoma DNA Hematology medicine.disease Peripheral T-cell lymphoma Lymphoma T-Cell Cutaneous Lymphoma Blotting Southern Skin biopsy Female medicine.symptom business |
| Zdroj: | American Journal of Hematology. 64:197-202 |
| ISSN: | 1096-8652 0361-8609 |
| Popis: | A primary cutaneous form of peripheral T-cell lymphoma (PTCL) and a low grade B-cell non-Hodgkin's lymphoma that was classified as a variant of hairy cell leukemia (HCL) were simultaneously diagnosed in a 79-year-old woman by both phenotypic and genotypic analyses. The coexistence of a T- and B-cell lymphoma in the same patient is rare, and, to our knowledge, this particular association has not been previously described. The patient was referred to our Department for evaluation of multiple cutaneous itchy, reddish plaques; laboratory analyses disclosed a lymphocytosis, that presented 6 years earlier. A bone marrow aspirate showed a 50% B-cell interstitial infiltrate, while a skin biopsy surprisingly revealed a PTCL. Clonality of both neoplastic processes was assessed by Southern blot analysis. The indolent clinical course of the cutaneous disease, and the low and stable number of circulating neoplastic T cells supported the diagnosis of a mycosis fungoides (MF)-like PTCL. Possible oncogenic events and/or putative underlying viral infections which could have played a role in the occurrence of B- and T-cell non-Hodgkin's lymphomas in the same patient are discussed. |
| Databáze: | OpenAIRE |
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