Maternal chlormequat chloride exposure disrupts embryonic growth and produces postnatal adverse effects
| Autor: | Qi Zhang, Xiaohong Hou, Bayindala Xiagedeer, Chenping Kang, Qianqian Xiao, Hong Hu, Weidong Hao |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Chlormequat medicine.medical_treatment Embryonic Development Biology Toxicology Growth Hormone-Releasing Hormone Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Plant Growth Regulators Bone Density Pregnancy Internal medicine medicine Animals Insulin-Like Growth Factor I Growth factor Embryogenesis Abnormalities Drug-Induced Embryo medicine.disease Rats 030104 developmental biology Endocrinology Somatostatin chemistry Animals Newborn Gene Expression Regulation Maternal Exposure Growth Hormone Body Composition Gestation Female 030217 neurology & neurosurgery Hormone |
| Zdroj: | Toxicology. 442 |
| ISSN: | 1879-3185 |
| Popis: | We showed previously that chlormequat chloride, a widely used plant growth regulator, could affect embryonic growth and growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis of rats. However, the potential effects of low dose chlormequat chloride exposure during pregnancy on embryonic and postnatal growth and development remain unclear. To further assess the risk of chlormequat chloride to human embryonic growth and postnatal health, we exposed maternal rats orally to the chemical during pregnancy at 5 mg/kg bw, a dose corresponding to the human acceptable daily intake (ADI) level set by World Health Organization (WHO), and determined the effects of chlormequat on embryo growth and postnatal health. We found that chlormequat chloride increased embryonic growth parameters, GH, and GH-releasing hormone (GHRH) levels, but did not affect somatostatin and IGF-1 on gestational day (GD) 11. In the pups of postnatal day (PD) 7, we observed increased head length, decreased body fat percentage, hypoglycemia, hyperlipidemia and hyperproteinemia. In conclusion, maternal exposure to chlormequat chloride during pregnancy disrupts the embryonic growth probably through its effects on growth regulators and even has adverse effects on postnatal health. |
| Databáze: | OpenAIRE |
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