The Charles River 'hairless' rat mutation maps to chromosome 1: allelic with fuzzy and a likely orthologue of mouse frizzy
| Autor: | I. M. Crooks, K. Ahearn, S. Grable, C. Lavoie, M. Pitruzzello, T. A. Stoklasek, J. Lanza, R. R. Chrissluis, R. Sharma, Thomas R. King, R. A. Maloney, G. Akkouris, A. K. Dull, J. Tweeddale, P. R. Berry, J. Jeruzal |
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| Rok vydání: | 2002 |
| Předmět: |
Male
animal structures Biology Hypotrichosis Genome Rats Mutant Strains Chromosome 15 Mice Genetics medicine Animals Allele Molecular Biology Genetics (clinical) Alleles Crosses Genetic Mice Hairless integumentary system Chromosome Chromosome Mapping Rats Inbred Strains medicine.disease Molecular biology Hairless Rats MYL2 Mutation (genetic algorithm) Mutation Female Biotechnology Hair |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0022-1503 |
| Popis: | Recent evidence has indicated that the recessive mutation affecting hypotrichosis in the Charles River (CR) "hairless" rat does not involve the hairless gene (hr) on rat chromosome 15. To determine if this mutation might be allelic (or orthologous) with any other previously mapped hypotrichosis-generating mutation in mammals, we have produced a panel of backcross rats segregating for the CR hairless rat mutation as well as numerous other markers from throughout the rat genome. Analysis of this panel has located the CR hairless rat's hypotrichosis-generating mutation on chromosome 1, near Myl2, where only the fuzzy mutation in rat (fz) and the frizzy mutation in mouse (fr) have been previously localized. Intercrossing fz/fz and CR hairless rats produced hybrid offspring with abnormal hair, showing that these two rat mutations are allelic. We suggest that the CR hairless rat mutation and fuzzy be renamed frizzy-Charles River (fr C R ) and frizzy-Harlan (fr H ), respectively, to reflect their likely orthology with the mouse fr mutation. |
| Databáze: | OpenAIRE |
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