A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms
| Autor: | Rosalie W. M. Kempkes, Janneke Elzinga, Julia M. L. Menon, Bea Zoer, Cathalijn H. C. Leenaars, Pim Drinkenburg, Jennifer Freymann, Koen Jakobs, Thomas J. Van Ee |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN) |
| Rok vydání: | 2018 |
| Předmět: |
circadian rhythm
0301 basic medicine Microdialysis Taurine Amino acids Histamine Systematic map Physiology Review 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Circadian rhythm Asparagine lcsh:QH301-705.5 chemistry.chemical_classification Endocrine and Autonomic Systems Chemistry Amino acid Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] Glutamine 030104 developmental biology lcsh:Biology (General) Biochemistry Glycine 030217 neurology & neurosurgery Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | Journal of Circadian Rhythms, 16, 12 Journal of Circadian Rhythms, Vol 16, Iss 1 (2018) Journal of Circadian Rhythms; Vol 16 (2018); 12 Journal of Circadian Rhythms, 16. BioMed Central Journal of Circadian Rhythms, 16, pp. 12 Journal of Circadian Rhythms |
| ISSN: | 1740-3391 |
| Popis: | Contains fulltext : 200413.pdf (Publisher’s version ) (Open Access) Background: Microdialysis can be used to measure amino acids in the extracellular space in vivo, based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms. Method: We systematically searched and mapped the literature on all studies reporting baseline microdialysis measurements of histamine and the amino acids asparagine, aspartate, GABA, glutamate, glutamine, glycine, proline and taurine. We fully reviewed the studies describing circadian rhythms for histamine and the selected amino acids. Results: We retrieved 2331 papers describing baseline measurements of one or more of the compounds of interest. We provide a numerical summary and lists of the publications by compound. We retrieved 11 references describing studies on the circadian rhythms of the compounds of interest. Aspartate, glutamate and histamine are generally higher during the dark than during the light phase in nocturnal rodents. For glutamine, no rhythmicity was observed. For GABA, the results were too inconsistent to generalise. For asparagine, glycine, proline and taurine, insufficient data are available. Conclusion: The literature on intracerebral microdialysis measurements of the amino acids is vast, but certain primary studies are still warranted. Future systematic reviews on the individual compounds can shed light on the effects of experimental variations on baseline concentrations. |
| Databáze: | OpenAIRE |
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