MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome

Autor: Gabriele Stocco, Eva Cuzzoni, Annalisa Marcuzzi, Giovanni Montini, Elena Monti, Marco Pelin, Diego Favretto, Andrea Pasini, Luciana Ghio, Claudio La Scola, Francesca Mencarelli, Giuliana Decorti, William Morello, Raffaella Franca, Marianna Lucafò, Sara De Iudicibus
Přispěvatelé: Cuzzoni, E., Franca, R., De Iudicibus, S., Marcuzzi, A., Lucafo, M., Pelin, M., Favretto, D., Monti, E., Morello, W., Ghio, L., La Scola, C., Mencarelli, F., Pasini, A., Montini, G., Decorti, G., Stocco, G., Cuzzoni, E, Colturi, F, De Iudicibus, S, Marcuzzi, A, Lucafo, M, Pelin, M, Favretto, D, Monti, E, Morello, W, Ghio, L, La Scola, C, Mencarelli, F, Pasini, A, Montini, G, Decorti, G, Stocco, G
Rok vydání: 2019
Předmět:
Male
Drug
medicine.medical_specialty
Nephrotic Syndrome
Adolescent
media_common.quotation_subject
medicine.medical_treatment
Drug Resistance
Idiopathic Nephrotic Syndrome
Pediatrics
030226 pharmacology & pharmacy
Gastroenterology
NO
Steroid
03 medical and health sciences
Idiopathic nephrotic syndrome
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Child
Macrophage Migration-Inhibitory Factors
Cytokine
media_common
Pharmacology
Polymorphism
Genetic
Proteinuria
business.industry
Cytokines
Glucocorticoid response
Cytokines
Glucocorticoid response
Idiopathic nephrotic syndrome
Pediatrics
General Medicine
Plasma levels
Intramolecular Oxidoreductases
Child
Preschool
Cohort
Female
Steroids
Macrophage migration inhibitory factor
medicine.symptom
business
Zdroj: European Journal of Clinical Pharmacology. 75:1675-1683
ISSN: 1432-1041
0031-6970
DOI: 10.1007/s00228-019-02749-3
Popis: Purpose: Idiopathic nephrotic syndrome (INS) is the most frequent form of childhood nephrotic syndrome. Steroids represent the best therapeutic option; however, inter-individual differences in their efficacy and side effects have been reported. To date, there is no way to predict patients’ resistance and/or dependence. Alterations in the cytokine profile of INS patients might contribute to proteinuria and glomerular damage and affect drug sensitivity. Methods: The cytokine plasma levels were measured in 21 INS children at diagnosis to investigate the association among cytokines pattern and clinical response. Patients were selected on the basis of their clinical response: 7 steroid sensitive (SS), 7 dependent (SD), and 7 resistant (SR). Significant results were then analyzed in 41 additional pediatric INS patients. Results: Within the 48 cytokines analyzed, macrophage migration inhibitory factor (MIF) was a good predictor of steroid response. Indeed, SR patients showed significantly higher MIF plasma levels compared with all others (p = 0.022; OR = 4.3, 95%CI = 1.2–25.4): a cutoff concentration of MIF > 501 pg/ml significantly discriminated SR patients (sensitivity = 85.7%, specificity = 71.4%). On the contrary, SD patients showed lower MIF plasma levels compared with others (p = 0.010; OR = 0.12, 95%CI = 9.2 × 10−3–6.7 × 10−1). Significant results were confirmed in the entire cohort. Conclusions: Our comprehensive cytokine analysis indicates that assessing MIF plasma levels at diagnosis could predict response to glucocorticoids in children with INS.
Databáze: OpenAIRE
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