Dual-Drug Backboned Polyprodrug with a Predefined Drug Combination for Synergistic Chemotherapy
| Autor: | Xinqing Jiang, Xuan Xiao, Ruimeng Yang, Shiwei Luo, Youyong Yuan, Maolin Jiang, Yalan Tu, Fangzhou Yu, Wang Yao |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
Curcumin medicine.medical_treatment media_common.quotation_subject Antineoplastic Agents Bioengineering 02 engineering and technology Drug resistance Pharmacology chemistry.chemical_compound Drug Delivery Systems In vivo Cell Line Tumor medicine General Materials Science media_common Drug Carriers Chemotherapy Mitoxantrone Mechanical Engineering Combination chemotherapy General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Drug Combinations Drug Liberation Pharmaceutical Preparations chemistry Cancer cell Nanoparticles 0210 nano-technology medicine.drug |
| Zdroj: | Nano Letters. 21:2216-2223 |
| ISSN: | 1530-6992 1530-6984 |
| Popis: | The codelivery of drugs at specific optimal ratios to cancer cells is vital for combination chemotherapy. However, most of the current strategies are unable to coordinate the loading and release of drug combinations to acquire precise and controllable synergistic ratios. In this work, we designed an innovative dual-drug backboned and reduction-sensitive polyprodrug PEG-P(MTO-ss-CUR) containing the anticancer drugs mitoxantrone (MTO) and curcumin (CUR) at an optimal synergistic ratio to reverse drug resistance. Due to synchronous drug activation and polymer backbone degradation, drug release at the predefined ratio with a synergistic anticancer effect was demonstrated by in vitro and in vivo experiments. Therefore, the dual-drug delivery system developed in this work provides a novel and efficient strategy for combination chemotherapy. |
| Databáze: | OpenAIRE |
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