Genetic variants in EBV reactivation-related genes and the risk and survival of breast cancer
| Autor: | Xue Fen Su, Lu Ying Tang, Ze Fang Ren, Wei Zhang, Ying Lin, Feng Xi Su, Xiaoming Xie, Zheng Zheng Zhang |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Oncology China Herpesvirus 4 Human medicine.medical_specialty Genotype Breast Neoplasms Single-nucleotide polymorphism 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Allele Gene Alleles Polymorphism Genetic Activating Transcription Factor 2 Endosomal Sorting Complexes Required for Transport business.industry Hazard ratio Genetic Variation General Medicine Odds ratio Middle Aged Prognosis medicine.disease Confidence interval DNA-Binding Proteins Survival Rate Ebv reactivation 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female Virus Activation business Follow-Up Studies Transcription Factors |
| Zdroj: | Tumor Biology. 37:8337-8347 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1007/s13277-015-4562-0 |
| Popis: | Tumor susceptibility gene 101 (TSG101) and activating transcription factor 2 (ATF2) have been suggested to involve in the reactivation of EBV which has implications in the development and progression of breast cancer. Therefore, the polymorphisms of TSG101 and ATF2 may associate with breast cancer risk and prognosis. A case-control study with 1551 breast cancer cases and 1605 age-matched controls were conducted in Guangzhou, China. We have also successfully followed up 1168 cases until December 31, 2014. The variant allele of TSG101 rs2292179 was associated with a non-significant reduced risk of breast cancer, particularly among women with BMI |
| Databáze: | OpenAIRE |
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