Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma

Autor: Gamal Osman, Ahmed M. Elsayed, Walid S.H. Elsayed, Ola A. Harb, Adel Mahmoud Morsy, Ahmed A. Obaya, Amrallah A. Mohammed, Ahmed S Allam, Hanaa Rashied
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Asian Pacific Journal of Cancer Prevention : APJCP
ISSN: 2476-762X
1513-7368
Popis: Background: Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn’t satisfactory. Methods: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed. Results: High Amphiregulin, PTEN and low P21 expression levels were associated with low tumor grade (p= 0.038 and 0.025 respectively), better response to anti-EGFR treatment (p
Databáze: OpenAIRE