Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma
Autor: | Gamal Osman, Ahmed M. Elsayed, Walid S.H. Elsayed, Ola A. Harb, Adel Mahmoud Morsy, Ahmed A. Obaya, Amrallah A. Mohammed, Ahmed S Allam, Hanaa Rashied |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
P21-immunohistochemistry Male PTEN Anti-EGFR treatment Colorectal cancer Phosphatase Value (computer science) Improved survival Antineoplastic Agents Amphiregulin Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Tensins medicine Biomarkers Tumor Tensin Humans Neoplasm Metastasis Aged biology business.industry General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Phosphoric Monoester Hydrolases ErbB Receptors 030104 developmental biology 030220 oncology & carcinogenesis Cancer research biology.protein Female business Colorectal Neoplasms metastatic colorectal carcinoma Research Article |
Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
ISSN: | 2476-762X 1513-7368 |
Popis: | Background: Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn’t satisfactory. Methods: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed. Results: High Amphiregulin, PTEN and low P21 expression levels were associated with low tumor grade (p= 0.038 and 0.025 respectively), better response to anti-EGFR treatment (p |
Databáze: | OpenAIRE |
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