Evaluation of Contrast-Enhanced Ultrasound of the Pancreas Combined with Concurrent Hormone Stimulation
| Autor: | Carsten Palnæs Hansen, Lars Bo Svendsen, Hanne Sønder Grossjohann, M. Bachmann Nielsen, Karin Nielsen, F Stadil |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Swine Urology Contrast Media Sensitivity and Specificity Secretin Internal medicine medicine Animals Radiology Nuclear Medicine and imaging Pancreas Ultrasonography Cholecystokinin Laparotomy business.industry Area under the curve Echogenicity Blood flow Image Enhancement Endocrinology medicine.anatomical_structure business Blood Flow Velocity Hormone Contrast-enhanced ultrasound |
| Zdroj: | Ultraschall in der Medizin - European Journal of Ultrasound. 29:520-524 |
| ISSN: | 1438-8782 0172-4614 |
| Popis: | PURPOSE To evaluate the potential of combined administration of the gastrointestinal hormones secretin (Secrelux) and c-terminal cholecystokinin (CCK-8 s) together with contrast-enhanced ultrasound (CE-US) to generate an extended contrast enhancement of healthy pancreatic tissue. MATERIALS AND METHODS 14 anaesthetised pigs weighing 30-35 kg were studied. After laparotomy, the pancreas was located and a B-mode examination followed by a CE-US examination of the gland was made using SonoVue 1.5 ml. After an injection of Secrelux 1 U/kg and CCK-8 s 100 pmol/kg, a second CE-US examination was conducted. The hormones and the contrast agent were administered through a catheter in the superior vena cava. The sonographic images were stored for later evaluation. RESULTS The study showed that CE-US increased the echogenicity of the pancreas by an average of 15.6 decibel (dB) (confidence intervals [CI]: 13.72, 17.42) p < 0.0001, an increase of 24%. The administration of Secrelux and CCK-8 s in combination with CE-US further increased the echogenicity of the pancreas by an average of 3% (CI: 0.36, 5.36) p = 0.028. A new sequence of hormones and CE-US 20 min after the previous injection did not induce further enhancement. The area under the curve (AUC) was significantly larger using both hormones and CE-US compared with CE-US alone by an average of 66 dBx sec (CI: 28,103) p = 0.002. CONCLUSION It is possible to generate an extended contrast enhancement of healthy pancreatic tissue using CE-US combined with the administration of the gastrointestinal hormones secretin (Secrelux) and c-terminal cholecystokinin (CCK-8 s). Our results may improve the ability to discriminate between healthy pancreatic tissue and areas with a changed blood flow due to either neoplasm or other pathological lesions. |
| Databáze: | OpenAIRE |
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