Biological Therapies in Osteoarthritis
| Autor: | Michael P. McDermott, Claire Y J Wenham, Philip G. Conaghan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
Biological therapies medicine.medical_specialty Tumor Necrosis Factor-alpha business.industry Anti-Inflammatory Agents Non-Steroidal Osteoarthritis medicine.disease Bioinformatics Symptom relief Drug Discovery Physical therapy Humans Intercellular Signaling Peptides and Proteins Medicine business Interleukin-1 |
| Zdroj: | Current Pharmaceutical Design. 21:2206-2215 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612821666150310144940 |
| Popis: | Given the paucity of effective therapies and the increasing prevalence of osteoarthritis (OA) with ageing and overweight populations, new therapies for this painful, life-impairing condition are desperately needed, for both symptom relief and structural modification. With a growing understanding that OA involves multiple tissue pathologies including inflammation, many more therapeutic targets have been identified. This review will provide a current overview on the role of biologics in OA, including anti-tumour necrosis factor agents, growth factors and interleukin-1 antagonists. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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