Dynamic Interleukin-6 Level Changes as a Prognostic Indicator in Patients With COVID-19
| Autor: | Xinghuan Wang, Liang Guo, Xiaohui Wu, Yihui Huang, Danyang Chen, Wei Long, Zeming Liu, Wen Zeng, Jinpeng Li, Sichao Chen, Man Li, Rongfen Gao, Jianglong Huang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty infectious disease Lung injury Logistic regression 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Pharmacology (medical) lung injury Interleukin 6 Original Research Pharmacology biology SARS-CoV-2 business.industry Proportional hazards model interleukin-6 Mortality rate lcsh:RM1-950 Hazard ratio COVID-19 Odds ratio CT scores Confidence interval lcsh:Therapeutics. Pharmacology 030104 developmental biology 030220 oncology & carcinogenesis biology.protein business |
| Zdroj: | Frontiers in Pharmacology, Vol 11 (2020) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| Popis: | Background: Interleukin-6 (IL-6), a proinflammatory cytokine, has been reported to be associated with disease severity and mortality in patients with coronavirus disease 2019 (COVID-19). Yet, dynamic changes in IL-6 levels and their prognostic value as an indicator of lung injury in COVID-19 patients have not been fully elucidated. Objective: To validate whether IL-6 levels are associated with disease severity and mortality and to investigate whether dynamic changes in IL-6 levels might be a predictive factor for lung injury in COVID-19 patients. Methods: This retrospective, single-center study included 728 adult COVID-19 patients and used data extracted from electronic medical records for analyses. Results: We included 120 and 608 patients in the elevated and normal IL-6 groups, respectively. The mortality rate was higher in the elevated IL-6 group than in the normal IL-6 group. Cox proportional hazards and logistic regression analyses for survival (adjusted hazard ratio, 10.39; 95% confidence interval [CI], 1.09–99.23; p=0.042) and disease severity (adjusted odds ratio, 3.56; 95% CI, 2.06–6.19; p |
| Databáze: | OpenAIRE |
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