How to study anxiety and depression in rodent models of chronic pain?
Autor: | Mélanie Kremer, Michel Barrot, Léa J. Becker, Ipek Yalcin |
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Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
Rok vydání: | 2020 |
Předmět: |
Rodentia
Comorbidity models 03 medical and health sciences 0302 clinical medicine Fibromyalgia medicine Animals Humans pain Depression (differential diagnoses) 030304 developmental biology Depressive Disorder Major 0303 health sciences [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior business.industry General Neuroscience Chronic pain anxiety medicine.disease Mood disorders depression Neuropathic pain tests Major depressive disorder Anxiety Chronic Pain medicine.symptom business 030217 neurology & neurosurgery Clinical psychology |
Zdroj: | European Journal of Neuroscience European Journal of Neuroscience, Wiley, In press, ⟨10.1111/ejn.14686⟩ |
ISSN: | 1460-9568 0953-816X |
Popis: | International audience; Mood disorders such as depression and anxiety are frequently observed in patients suffering from chronic pain. Over time, different tests and models have been developed in rodents to study the anxiodepressive‐like consequences of chronic pain. This review describes these preclinical tools (models and tests) used for studying behavioural aspects of the comorbid relationship between chronic pain and anxiety and/or major depressive disorder. Three major types of chronic pain strongly associated with anxiodepressive‐like comorbidity as well as their animal models are presented: neuropathic pain, inflammatory pain and fibromyalgia. After a description of chronic pain animal models and of the tests that allow determining nociceptive responses, this review presents and discusses the various behavioural tests that have been used to assess anxiety and depressive‐like behaviours in these models of chronic pain. Finally, this review highlights the progress that remains to be made to homogenize the results in the field of pain‐induced mood disorders and summarizes the recent advances achieved through these tests and models. |
Databáze: | OpenAIRE |
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