D-homoandrostanes.4. The incubation of some D-homo-5α-androstanes with Rhizopus nigricans
| Autor: | Deanna De Marcano, Ivonne Ludovic, Eleida Garcia, Ladislav Kohout, John M. Evans, María Narvaez, JoséF. del Giorgio |
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| Rok vydání: | 1983 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry medicine.medical_treatment Clinical Biochemistry Molecular Conformation Rhizopus nigricans Biochemistry Steroid Hydroxylation Structure-Activity Relationship chemistry.chemical_compound Endocrinology Stereospecificity Biotransformation medicine Androstanes Molecular Biology Incubation Pharmacology biology Organic Chemistry Nuclear magnetic resonance spectroscopy biology.organism_classification chemistry Homosteroids Rhizopus |
| Zdroj: | Steroids. 41:1-13 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(83)90011-9 |
| Popis: | Nine dioxygenated D-homoandrostanes were incubated with Rhizopus nigricans to investigate the effect of D-ring modification on microbiological hydroxylation. Structure determination of the products by NMR spectroscopy, and in certain cases independent synthesis of their oxidised products, showed that in contrast to 5 alpha-androstanes the majority of the compounds were hydroxylated in the "reverse" mode, and only D-homo-5 alpha-androstane-3,17-dione was hydroxylated in the "normal" mode to any extent. Stereospecific ring D-hydroxylation at C(17 alpha) was observed for both D-homo-5 alpha-androstane-3,6- and 3,7-diones. |
| Databáze: | OpenAIRE |
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