Evaluation of Intussusception after Monovalent Rotavirus Vaccination in Africa
| Autor: | Tate, Jacqueline E, Mwenda, Jason M, Armah, George, Jani, Bhavin, Omore, Richard, Ademe, Ayesheshem, Mujuru, Hilda, Mpabalwani, Evans, Ngwira, Bagrey, Cortese, Margaret M, Mihigo, Richard, Glover-Addy, Hope, Mbaga, Mwajabu, Osawa, Francis, Tadesse, Amezene, Mbuwayesango, Bothwell, Simwaka, Julia, Cunliffe, Nigel, Lopman, Benjamin A, Weldegebriel, Goitom, Ansong, Daniel, Msuya, David, Ogwel, Billy, Karengera, Thomas, Manangazira, Portia, Bvulani, Bruce, Yen, Catherine, Zawaira, Felicitas R, Narh, Clement T, Mboma, Lazaro, Saula, Peter, Teshager, Fasil, Getachew, Halle, Moeti, Rebecca M, Eweronu-Laryea, Christabel, Parashar, Umesh D, African Intussusception Surveillance Network |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty biology business.industry Incidence (epidemiology) General Medicine medicine.disease Rotavirus vaccination biology.organism_classification Vaccination 03 medical and health sciences 0302 clinical medicine Tanzania Immunization Vaccination status 030225 pediatrics Intussusception (medical disorder) parasitic diseases Human rotavirus medicine 030212 general & internal medicine business |
| Zdroj: | The New England journal of medicine |
| Popis: | Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries.Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria. Rotavirus vaccination status was confirmed by review of the vaccine card or clinic records. The risk of intussusception within 1 to 7 days and 8 to 21 days after vaccination among infants 28 to 245 days of age was assessed by means of the self-controlled case-series method.Data on 717 infants who had intussusception and confirmed vaccination status were analyzed. One case occurred in the 1 to 7 days after dose 1, and 6 cases occurred in the 8 to 21 days after dose 1. Five cases and 16 cases occurred in the 1 to 7 days and 8 to 21 days, respectively, after dose 2. The risk of intussusception in the 1 to 7 days after dose 1 was not higher than the background risk of intussusception (relative incidence [i.e., the incidence during the risk window vs. all other times], 0.25; 95% confidence interval [CI] |
| Databáze: | OpenAIRE |
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