Chromophores in operative surgery: Current practice and rationalized development
| Autor: | Sofia Teixeira, Siân-Eleri Owens, Maxwell Murison, M. Anne Sawhney, Lewis Francis, Daniel J. Rees, Iain S. Whitaker, Marc Clement, R. Steven Conlan, Ernest A. Azzopardi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Light Exploit Infrared Rays Ultraviolet Rays Contrast Media Pharmaceutical Science Nanotechnology Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Neoplasms Animals Humans Medicine Coloring Agents Anaphylaxis business.industry Operative surgery Optically active 030104 developmental biology Risk analysis (engineering) Feature (computer vision) Current practice Surgical Procedures Operative 030220 oncology & carcinogenesis business |
| Zdroj: | Journal of Controlled Release. 249:123-130 |
| ISSN: | 0168-3659 |
| Popis: | Background Chromophore-containing molecules feature extensively in surgical practice, with synthetic dyes gaining popularity over endogenous optical adjuncts. New applications for chromophores in diagnostics and operative treatment exploit unique chemical structures suited for illuminating target tissues beyond the visual spectrum, ranging from ultraviolet (UV) to near-infrared (NIR). This review outlines the rationale for surgical chromophore application, the weaknesses and risks in each class of these compounds, and areas of foreseeable potential for employment of specialized contrast agents. Method An English-language literature search applied the following Boolean Search String: “dye OR Lake OR Stain OR chromophore” AND “tox$ OR terato* OR carcino$ OR Allerg$ OR surg$ OR clinic” using EMBASE, PUBMED, PUBMED central and OVIDSp, with back-referencing through Web of Knowledge™. Results Based on the primary literature, this study proposes a surgically relevant classification system of chromophores in current use, which facilitates risk/benefit consideration for the surgeon who employs them, and which facilitates clinically oriented development. Conclusions The next stage of development for optically active surgical adjuncts must address practical constraints whilst minimizing risks of adverse effects. Exploiting the technology's full potential also requires improvements in the usefulness of imagery equipment. |
| Databáze: | OpenAIRE |
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