Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer
| Autor: | Man-Jeong Paik, Ik Joo Chung, Chathurika D.B. Gamage, Kyung Keun Kim, Myong-Suk Park, Woo Kyun Bae, Yong Jae Choi, Ji-Yoon Lee, İsa Taş, Jae-Seoun Hur, Jae Hyuk Lee, Hangun Kim, Yi Yang, Rui Zhou, Young Hyun Yu, Kyung-Hwa Lee, Hyung-Ho Ha, So-Yeon Park, Sang Kyum Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Epithelial-Mesenchymal Transition Slug Colorectal cancer Administration Oral Biological Availability lcsh:Medicine Antineoplastic Agents Selenic Acid Article Metastasis 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine In vivo Oral administration Cell Movement Cell Line Tumor medicine Animals Humans Neoplasm Invasiveness lcsh:Science Benzofurans Cell Proliferation Multidisciplinary biology lcsh:R Usnic acid medicine.disease biology.organism_classification In vitro Bioavailability Gene Expression Regulation Neoplastic Disease Models Animal 030104 developmental biology Treatment Outcome chemistry 030220 oncology & carcinogenesis Cancer research Potassium lcsh:Q Drug Screening Assays Antitumor Colorectal Neoplasms |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor, liver, and plasma of a CT26 syngeneic mouse tumor xenograft model after oral administration, as determined by LC-MS/MS analysis. KU exhibited potent anticancer effects on colorectal cancer cells and inhibited liver metastasis in an orthotopic murine colorectal cancer model. KU treatment downregulated the epithelial-mesenchymal markers Twist, Snail, and Slug and the metastasis-related genes CAPN1, CDC42, CFL1, IGF1, WASF1, and WASL in cells and tumor tissues. The present results suggest the potential application of the water-soluble form of UA, KU, in anticancer therapy. |
| Databáze: | OpenAIRE |
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