Possible mechanisms of the hypoglycaemic effect of artesunate: Gender implication
| Autor: | Sheu Oluwadare Sulaiman, Toyin Mohammad Salman, Abdullateef Isiaka Alagbonsi, Susan Kebu, Kafayat Anike Adedini |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Glycogenolysis Antioxidant Physiology medicine.medical_treatment Artesunate QD415-436 Biochemistry Glucagon chemistry.chemical_compound Internal medicine Male rats medicine Increased glycogen High doses QP1-981 Insulin Sex hormones Glucose-6-phosphate business.industry General Medicine Original Research Paper Glucose Endocrinology chemistry business |
| Zdroj: | Metabolism Open Metabolism Open, Vol 10, Iss, Pp 100087-(2021) |
| DOI: | 10.21203/rs.3.rs-56127/v1 |
| Popis: | Background We investigated the mechanism of artesunate’s glucose-modulating effect especially with gender implication. Methods Twenty-five (25) male and 25 female rats were separately and blindly allocated into five identical groups (n = 5/group). Group I (control) received 0.2 ml/kg distilled water. Groups II and III both received 2.90 mg/kg artesunate on day one, but 1.45 mg/kg from day two till day five and day fifteen respectively. Groups IV and V both received 8.70 mg/kg artesunate on day one, but 4.35 mg/kg artesunate from day two till day five and day fifteen respectively. Results In male rats, glucose was reduced by both doses of artesunate at 5 days but increased by high dose at 15 days. Artesunate increased glycogen concentration at short duration which normalised at long duration in both genders. Artesunate increased G6P concentration only in male rats at 15 days but reduced G6Pase activity in male and female rats (except in those that received low and high doses of artesunate for 15 days). Artesunate increased insulin only in male rats treated with low dose artesunate for 5 days. Artesunate increased cortisol concentration in male but reduced it in female rats. Artesunate decreased glucagon concentration except in female rats treated with high dose for 5 days. Artesunate increased oestrogen concentration in male rats that received low dose artesunate for 5 days but reduced it in female rats that received high dose for 15 days. Conclusions Artesunate reduces plasma glucose by reducing plasma glucagon concentrations and inhibiting liver glycogenolysis via inhibition of G6Pase activity in both sexes. Increase in insulin concentration contributed to the reduction in blood glucose caused by artesunate in male but not female rats; and artesunate-induced increase in G6P, a substrate for G6PD, could enhance NADPH generation and antioxidant enzyme activation in male rats. Highlights • Reducing glucagon concentration and inhibiting G6Pase activity in both genders. . • Increasing plasma insulin in male but not in female. • Increasing G6P, a substrate for G6PD, in male rats. |
| Databáze: | OpenAIRE |
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