Complete nucleotide sequence of a norovirus GII.4 genotype: evidence for the spread of the newly emerged pandemic Sydney 2012 strain to China

Autor:	Yuqi Huo, Jiaxin Yan, Ailing Cai, Hui Yang, Shuo Shen, Mingli Zhou, D. X. Liu
Rok vydání:	2013
Předmět:	Genetics China Genes Viral Genotype viruses Strain (biology) Norovirus Nucleic acid sequence virus diseases General Medicine Biology medicine.disease_cause Virology fluids and secretions Capsid Phylogenetics Pandemic medicine Molecular Biology Gene Phylogeny
Zdroj:	Virus genes. 48(2)
ISSN:	1572-994X
Popis:	A newly emerged pandemic Sydney GII.4-like norovirus (NoV) (Jingzhou GII.4) was isolated in Jingzhou, China in April, 2013, demonstrating the rapid spread of the variant to China. The complete nucleotide sequence was compared with the prototype Sydney 2012 variant and its VP1 gene with that of Huzhou strain (isolated in January 2013 in Huzhou, China). The result demonstrates that the new variant has evolved rapidly, including mutations in the hypervariable P2 domain of the major capsid protein VP1. Our study also shows that the new Jingzhou GII.4 variant co-circulated with GII.3 and GI.2 at the same time, supporting further monitoring of the evolution of the new NoV variant in China.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b49f052542a5da954a3fe31e670b76a https://pubmed.ncbi.nlm.nih.gov/24282081 Zobrazit plný text záznamu Full text from SpringerLink