Extracranial metastases of high-grade glioma: the clinical characteristics and mechanism

Autor: Hao Jiang, Hongbo Xu, Rui Xu, Gengming Wang, Xueming Shen, Qian Sun
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Pathology
Review
Extracranial metastasis
Pathogenesis
Fatal Outcome
0302 clinical medicine
Surgical oncology
Positron Emission Tomography Computed Tomography
Antineoplastic Combined Chemotherapy Protocols
Epidemiology
Lymph node
Brain Neoplasms
Cancer Pain
Chemoradiotherapy
Glioma
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Magnetic Resonance Imaging
Temporal Lobe
medicine.anatomical_structure
Oncology
Lymphatic Metastasis
030220 oncology & carcinogenesis
Female
Occipital Lobe
Radiology
Lymph
Tomography
Emission-Computed
Adult
Sacrum
medicine.medical_specialty
lcsh:Surgery
Bone Neoplasms
lcsh:RC254-282
03 medical and health sciences
medicine
Humans
Pathological
Mechanism (biology)
business.industry
lcsh:RD1-811
medicine.disease
Surgery
Lymph Nodes
Neoplasm Grading
Radiotherapy
Conformal
business
030217 neurology & neurosurgery
Zdroj: World Journal of Surgical Oncology, Vol 15, Iss 1, Pp 1-5 (2017)
World Journal of Surgical Oncology
ISSN: 1477-7819
DOI: 10.1186/s12957-017-1249-6
Popis: Background This presentation of two cases and literature review discusses the epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment, and prognosis of high-grade glioma with extracranial metastases. Methods A retrospective analysis of the clinical features of two cases of malignant glioma, including metastatic sites, pathological data, and treatment methods, and a literature review was performed. Results Two patients developed extracranial metastases within 1 year after surgery for primary glioma. One patient developed cervical lymph node and bone metastases while the other developed bone metastases, and both patients died within 2 months after the diagnosis of the extracranial metastasis. Conclusion Extracranial metastases may develop from malignant gliomas. According to the literature, the most common extracranial site is intraspinal (along the neural axis), followed by the vertebrae, lungs, liver, and lymph nodes. The complex metastatic mechanism remains unclear, and the prognosis is very poor, with a survival duration of less than 6 months.
Databáze: OpenAIRE
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