Prevention of acute complications after percutaneous transluminal coronary angioplasty
| Autor: | Jacques Lespérance, Martial G. Bourassa, Clive Eastwood, Leonard Schwartz, Farouk Kazim |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Placebo Revascularization law.invention Electrocardiography Randomized controlled trial Double-Blind Method law Internal medicine Multicenter trial Angioplasty medicine Humans Myocardial infarction Angioplasty Balloon Coronary Creatine Kinase medicine.diagnostic_test Aspirin business.industry Hematology Dipyridamole Middle Aged medicine.disease Surgery Clinical trial Acute Disease Cardiology Drug Therapy Combination Female business Platelet Aggregation Inhibitors |
| Zdroj: | Thrombosis research. Supplement. 12 |
| ISSN: | 0896-0569 |
| Popis: | The prevention of major complications occurring during or early after percutaneous transluminal coronary angioplasty was evaluated in 376 patients in a randomized, double-blind, placebo-controlled multicenter trial. Starting 24 hours before angioplasty, 187 patients received an aspirin-dipyridamole combination and 189 were given placebo. There were no periprocedural deaths. Periprocedural non-fatal myocardial infarction was diagnosed in 34 patients (9.0%). Q wave myocardial infarction occurred in 16 patients: 3 (1.6%) in the aspirin-dipyridamole group and 13 (6.9%) in the placebo group (p = 0.0113). Non-Q wave myocardial infarction occurred in 18 patients: 6 (3.2%) in the active drug group and 12 (6.3%) in the placebo group (p = 0.1538). Emergency myocardial revascularization was performed in 9 patients in each treatment arm. Q wave myocardial infarction occurred following revascularization in 5 patients (55.5%) in the placebo group and in only 2 (22.2%, p = 0.1670) in the aspirin-dipyridamole group. Thus the incidence of periprocedural Q and non-Q wave myocardial infarction is high in patients not on antiplatelet therapy (13.2%) and is markedly lower in those on the aspirin-dipyridamole combination (4.8%, p = 0.0044). Short-term antiplatelet therapy before and after angioplasty can be recommended for patients who do not have contraindications to this medication. |
| Databáze: | OpenAIRE |
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