Combination chemotherapy with irinotecan and gemcitabine for taxane/platinum-resistant/refractory ovarian and primary peritoneal cancer: a multicenter phase I/II trial (GOGO-Ov 6)

Autor:	Kiyoshi Yoshino, Takeshi Yokoi, Ruriko Nakae, Tadashi Kimura, Masami Fujita, Masahiko Takemura, Shoji Kamiura, Tateki Tsutsui, Takuji Tomimatsu, Kazushige Adachi, Eiji Kobayashi, Seiji Mabuchi, Kenjiro Sawada, Yasuhiko Shiki, Yutaka Ueda, Kae Hashimoto, A. Wakimoto, Takamichi Nishizaki, Yuki Kanda
Rok vydání:	2017
Předmět:	Adult Bridged-Ring Compounds 0301 basic medicine Oncology Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty endocrine system diseases Irinotecan Toxicology Deoxycytidine 03 medical and health sciences chemistry.chemical_compound Peritoneal Neoplasm 0302 clinical medicine Refractory Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Pharmacology (medical) Prospective Studies Peritoneal Neoplasms Aged Platinum Ovarian Neoplasms Pharmacology Taxane business.industry Combination chemotherapy Middle Aged Gemcitabine female genital diseases and pregnancy complications 030104 developmental biology chemistry 030220 oncology & carcinogenesis Camptothecin Female Taxoids business medicine.drug
Zdroj:	Cancer Chemotherapy and Pharmacology. 80:1239-1247
ISSN:	1432-0843 0344-5704
Popis:	To develop a new therapeutic strategy for taxane/platinum-resistant/refractory ovarian and primary peritoneal cancers, we evaluated the feasibility and efficacy of irinotecan and gemcitabine combination chemotherapy.Patients with taxane/platinum-resistant/refractory cancer received escalating doses of irinotecan and gemcitabine (level 1: 80 and 800 mg/mA total of 35 patients were enrolled. The recommended dose was defined as 100 mg/mCombination chemotherapy with irinotecan and gemcitabine represents a safe and effective treatment combination for taxane/platinum-resistant/refractory ovarian and primary peritoneal cancers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4687cc4b6c4cb0b7bebf456c80f24d https://doi.org/10.1007/s00280-017-3468-5 Zobrazit plný text záznamu Full text from SpringerLink