Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine
| Autor: | Suman K. Samanta, Narayan Chandra Talukdar, Paramita Choudhury, Bikas C. Pal, Bhaskarjyoti Gogoi, Raghuram Kandimalla, Krishna Dutta, Rajlakshmi Devi, Prashanta Kumar Deb |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Murraya medicine.drug_class Phytochemicals Carbazoles Antineoplastic Agents Pharmacology 03 medical and health sciences 0302 clinical medicine Active component Antidiarrhoeal medicine Animals Humans Research data Antitumor activity Primary (chemistry) biology Plant Extracts Chemistry biology.organism_classification 030104 developmental biology Phytochemical 030220 oncology & carcinogenesis Chemical constituents |
| Zdroj: | Pharmacological Research. 129:227-236 |
| ISSN: | 1043-6618 |
| DOI: | 10.1016/j.phrs.2017.11.024 |
| Popis: | Murraya koenigii, a plant belonging to the Rutaceae family is widely distributed in Eastern-Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian system of medicine. Through systematic research and pharmacological evaluation of different parts of the plant extracts has been shown to possess antiviral, anti-inflammatory, antioxidant, antidiabetic, antidiarrhoeal, antileishmanial, and antitumor activity. In the plant extracts, carbazole alkaloid, mahanine has been identified as the principle bioactive component among several other chemical constituents. Scientific evidence derived not only from in vitro cellular experiments but also from in vivo studies in various cancer models is accumulating for the pronounced anticancer effects of mahanine. The primary objective of this review is to summarize research data on cytotoxic chemical constituents present in different parts of Murraya koenigii and the anticancer activity of mahanine along with the recent understanding on the mechanism of its action in diverse cancer models. The information on its bioavailability and the toxicity generated from the recent studies have also been incorporated in the review. |
| Databáze: | OpenAIRE |
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