Irbic acid, a dicaffeoylquinic acid derivative from Centella asiatica cell cultures
| Autor: | Sergio Crippa, Bruno Danieli, Giovanna Pressi, Anacleto Minghetti, Fabiana Antognoni, Ferruccio Poli, Roberto Dal Toso, Nicoletta Crespi Perellino |
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| Přispěvatelé: | F. Antognoni, N. Crespi Perellino, S. Crippa, R. Dal Toso, B. Danieli, A. Minghetti, F. Poli, G. Pressi |
| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Antioxidant APIACEAE CELL CULTURE medicine.medical_treatment Cell Culture Techniques Quinic Acid CENTELLA ASIATICA Pharmacognosy Mass Spectrometry Centella chemistry.chemical_compound Chlorogenic acid Drug Discovery medicine Collagenases Enzyme Inhibitors Pharmacology chemistry.chemical_classification Molecular Structure biology Plant Extracts Free Radical Scavengers General Medicine biology.organism_classification In vitro COLLAGENASE INHIBITORY ACTIVITY Enzyme Biochemistry chemistry Cell culture Collagenase ANTIOXIDANT ACTIVITY medicine.drug |
| Zdroj: | Fitoterapia. 82:950-954 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2011.05.008 |
| Popis: | 3,5-O-dicaffeoyl-4-O-malonilquinic acid (1) (irbic acid) has been isolated for the first time from cell cultures of Centella asiatica and till now it has never been reported to be present in the intact plant. Evidence of its structure was obtained by spectroscopic analyses (MS/NMR). Besides 1, cell cultures produce also the known 3,5-O-dicaffeoylquinic acid, chlorogenic acid, and the triferulic acid 2 (4-O-8′/4′-O-8″-didehydrotriferulic acid). Biological activities were evaluated for compound 1, which showed to have a strong radical scavenging capacity, together with a high inhibitory activity on collagenase. This suggests a possible utilization of this substance as a topical agent to reduce the skin ageing process. |
| Databáze: | OpenAIRE |
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