Evaluation of the overdiagnosis in breast screening programmes using a Monte Carlo simulation tool: a study of the influence of the parameters defining the programme configuration
Autor: | Antonio M. Lallena, L. I. Zamora, Damián Guirado, Cristina Forastero |
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Rok vydání: | 2019 |
Předmět: |
Adult
medicine.medical_specialty Monte Carlo method Population Breast Neoplasms Medical Overuse breast screening programmes overdiagnosis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Breast screening Humans Medical physics Computer Simulation False Positive Reactions Overdiagnosis education invasive/in-situ tumors Monte Carlo Early Detection of Cancer Aged education.field_of_study business.industry Incidence Research General Medicine Middle Aged medicine.disease Spain 030220 oncology & carcinogenesis Female Public Health Breast Carcinoma In Situ business Monte Carlo Method Mammography |
Zdroj: | BMJ Open |
ISSN: | 2044-6055 |
Popis: | ObjectivesTo build up and test a Monte Carlo simulation procedure for the investigation of overdiagnosis in breast screening programmes (BSPs).DesignA Monte Carlo tool previously developed has been adapted for obtaining the quantities of interest in order to determine the overdiagnosis: the annual and cumulative number of cancers detected by screening, plus interval cancers, for a population following the BSP, and detected clinically for the same population in the absence of screening. Overdiagnosis is obtained by comparing these results in a direct way.ResultsOverdiagnosis between 7% and 20%, depending on the specific configuration of the programme, have been found. These range of values is in agreement with some of the results available for actual BSPs. In the cases analysed, a reduction of 11% at most has been found in the number of invasive tumours detected by screening in comparison to those clinically detected in the control population. It has been possible to establish that overdiagnosis is almost entirely linked to ductal carcinoma in situ tumours.ConclusionsThe use of Monte Carlo tools may facilitate the analysis of overdiagnosis in actual BSPs, permitting to address the role played by various quantities of relevance for them. |
Databáze: | OpenAIRE |
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