Investigation of the Molecular Mechanism of Coagulopathy in Severe and Critical Patients With COVID-19
| Autor: | Daniel Elieh Ali Komi, Yaghoub Rahimi, Rahim Asghari, Reza Jafari, Javad Rasouli, Mehdi Mohebalizadeh, Ata Abbasi, Rahim Nejadrahim, Farzin Rezazadeh, Vahid Shafiei-Irannejad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Immunology antithrombin III (ATIII) coagulopathy Fibrin Fibrinogen Degradation Products Immunology and Allergy Homeostasis Humans Blood Coagulation Original Research Aged Fibrin SARS-CoV-2 COVID-19 protein C (PC) Blood Coagulation Disorders Middle Aged RC581-607 Prognosis Blood Coagulation Factors D-dimer (DD) Prothrombin Time Female Partial Thromboplastin Time Blood Coagulation Tests fibrinogen Immunologic diseases. Allergy protein S Protein C |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.762782/full |
| Popis: | Coagulopathy is a frequently reported finding in the pathology of coronavirus disease 2019 (COVID-19); however, the molecular mechanism, the involved coagulation factors, and the role of regulatory proteins in homeostasis are not fully investigated. We explored the dynamic changes of nine coagulation tests in patients and controls to propose a molecular mechanism for COVID-19-associated coagulopathy. Coagulation tests including prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen (FIB), lupus anticoagulant (LAC), proteins C and S, antithrombin III (ATIII), D-dimer, and fibrin degradation products (FDPs) were performed on plasma collected from 105 individuals (35 critical patients, 35 severe patients, and 35 healthy controls). There was a statically significant difference when the results of the critical (CRT) and/or severe (SVR) group for the following tests were compared to the control (CRL) group: PTCRT (15.014) and PTSVR (13.846) (PTCRL = 13.383, p CRT (42.923) and PTTSVR (37.8) (PTTCRL = 36.494, p CRT (49.414) and LACSVR (47.046) (LACCRL = 40.763, p CRT (537.66) and FIBSVR (480.29) (FIBCRL = 283.57, p CRT (85.57%) and ProCSVR (99.34%) (ProCCRL = 94.31%, p = 0.04), ProSCRT (62.91%) and ProSSVR (65.06%) (ProSCRL = 75.03%, p p χ2 = 34.812), and FDP (p χ2 = 15.205). No significant association was found in the ATIII results in groups (ATIIICRT = 95.71% and ATIIISVR = 99.63%; ATIIICRL = 98.74%, p = 0.321). D-dimer, FIB, PT, PTT, LAC, protein S, FDP, and protein C (ordered according to p-values) have significance in the prognosis of patients. Disruptions in homeostasis in protein C (and S), VIII/VIIIa and V/Va axes, probably play a role in COVID-19-associated coagulopathy. |
| Databáze: | OpenAIRE |
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