Dysplasia in Inflammatory Bowel Disease: Historical Review, Critical Histopathological Analysis, and Clinical Implications
| Autor: | Søren Laurberg, Anders Mark-Christensen, Najib Haboubi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer colorectal cancer Gastroenterology Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine dysplasia inflammatory bowel disease Internal medicine medicine Immunology and Allergy Humans endoscopy Irritable bowel syndrome Hyperplasia medicine.diagnostic_test business.industry Histopathological analysis medicine.disease Inflammatory Bowel Diseases Endoscopy Intestines Dysplasia 030220 oncology & carcinogenesis surveillance 030211 gastroenterology & hepatology business Colorectal Neoplasms |
| Zdroj: | Mark-Christensen, A, Laurberg, S & Haboubi, N 2018, ' Dysplasia in Inflammatory Bowel Disease: Historical Review, Critical Histopathological Analysis, and Clinical Implications ', Inflammatory Bowel Diseases, vol. 24, no. 9, pp. 1895-1903 . https://doi.org/10.1093/ibd/izy075 |
| ISSN: | 1536-4844 |
| Popis: | Colorectal cancer is the most serious complication of chronic inflammatory bowel disease. It is generally accepted that dysplasia in most cases precedes the development of colorectal cancer. Thus, detection of dysplasia through surveillance may allow therapeutic interventions to lower the risk of cancer. Our understanding of dysplasia has evolved over the past decades and guided rational decision-making, but many questions remain unanswered. We are currently at the brink of a new era, where new avenues in the endoscopic detection and management of dysplasia are pursued, and the paradigm of a colectomy being the preferred treatment for advanced neoplasia is changing. This review provides a histopathological characterization of dysplasia and aims at summarizing our current understanding of the disease from a clinical point of view. Management algorithms presented seek to aid clinicians and patients in dealing with dysplasia, and future perspectives are discussed. |
| Databáze: | OpenAIRE |
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