Relationship between Methyl Tertiary Butyl Ether Exposure and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study among Petrol Station Attendants in Southern China
| Autor: | Xiaochun Peng, Jianping Yang, Xiaowu Peng, Qinzhi Wei, Dalin Hu, Jianhui Yuan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Health Toxicology and Mutagenesis lcsh:Medicine Blood Pressure Environmental pollution 010501 environmental sciences 01 natural sciences Gastroenterology chemistry.chemical_compound 0302 clinical medicine Risk Factors Odds Ratio Prevalence Air Pollutants biology Fatty liver Alanine Transaminase Middle Aged Lipoproteins LDL Cholesterol Female 030211 gastroenterology & hepatology epidemiology Lipoproteins HDL Adult Methyl Ethers China medicine.medical_specialty Article 03 medical and health sciences Asian People Occupational Exposure Internal medicine medicine Humans Risk factor Triglycerides 0105 earth and related environmental sciences business.industry lcsh:R Public Health Environmental and Occupational Health methyl tertiary butyl ether non-alcoholic fatty liver disease Odds ratio medicine.disease Fatty Liver environmental pollution Cross-Sectional Studies Blood pressure chemistry Alanine transaminase biology.protein business Body mass index |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 13, Iss 10, p 946 (2016) International Journal of Environmental Research and Public Health; Volume 13; Issue 10; Pages: 946 International Journal of Environmental Research and Public Health |
| ISSN: | 1660-4601 |
| Popis: | Methyl tertiary butyl ether (MTBE)—A well known gasoline additive substituting for lead alkyls—causes lipid disorders and liver dysfunctions in animal models. However, whether MTBE exposure is a risk factor for non-alcoholic fatty liver disease (NAFLD) remains uncertain. We evaluate the possible relationship between MTBE exposure and the prevalence of NAFLD among 71 petrol station attendants in southern China. The personal exposure concentrations of MTBE were analyzed by Head Space Solid Phase Microextraction GC/MS. NAFLD was diagnosed by using abdominal ultrasonography according to the guidelines for the diagnosis and treatment of NAFLD suggested by the Chinese Hepatology Association. Demographic and clinical characteristics potentially associated with NAFLD were investigated. Mutivariate logistic regression analysis was applied to measure odds ratios and 95% confidence intervals (CI). The result showed that the total prevalence of NAFLD was 15.49% (11/71) among the study subjects. The average exposure concentrations of MTBE were 292.98 ± 154.90 μg/m3 and 286.64 ± 122.28 μg/m3 in NAFLD and non-NAFLD groups, respectively, and there was no statistically significant difference between them (p > 0.05). After adjusting for age, gender, physical exercise, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), white blood cell (WBC), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), the odds ratios were 1.31 (95% CI: 0.85–1.54; p > 0.05), 1.14 (95% CI: 0.81–1.32; p > 0.05), 1.52 (95% CI: 0.93–1.61; p > 0.05) in the groups (including men and women) with exposure concentrations of MTBE of 100–200 μg/m3, 200–300 μg/m3, and ≥300 μg/m3, respectively, as compared to the group (including men and women) ≤100 μg/m3. Our investigation indicates that exposure to MTBE does not seem to be a significant risk factor for the prevalence of NAFLD among petrol station attendants in southern China. |
| Databáze: | OpenAIRE |
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