Common features of F-18 FDG PET/CT findings in Scrub Typhus: prospective study before and after antibiotics therapy

Autor: Seung Hee Choi, Suhyun Kim, Mir Jeon, Yeon-Hee Han, Joo-Hee Hwang, Seok Tae Lim, Chang-Seop Lee, Yeon-Joon Kim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Orientia tsutsugamushi
030231 tropical medicine
lcsh:Medicine
Eschar
Scrub typhus
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Medicine
Humans
Prospective cohort study
Clinical microbiology
lcsh:Science
Aged
Fluorodeoxyglucose
Multidisciplinary
medicine.diagnostic_test
biology
business.industry
lcsh:R
Middle Aged
biology.organism_classification
medicine.disease
bacterial infections and mycoses
F 18 fdg pet ct
Anti-Bacterial Agents
carbohydrates (lipids)
Scrub Typhus
Positron emission tomography
Female
lcsh:Q
Radiology
Lymph Nodes
medicine.symptom
Bacterial infection
Radiopharmaceuticals
business
Generalized lymphadenopathy
Spleen
medicine.drug
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-019-51964-6
Popis: Scrub typhus is an acute febrile illness caused by obligate intracellular organism Orientia tsutsugamushi. While there have been many reports on the evaluation of disease activity and infectious diseases using F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), the clinical value of FDG PET/CT in scrub typhus has not been fully investigated. We enrolled 17 patients who were 18 years of age or older and clinically suspected of having scrub typhus with eschar. Clinical assessments, blood samples, and FDG PET/CT images were obtained at enrolment and again after 3 weeks. The median age of the patients was 65 years; 9 (52.9%) patients were male. On initial FDG PET/CT, the eschars showed markedly increased FDG uptake on PET imaging that improved after treatment. Generalized lymphadenopathy and splenomegaly with high FDG uptake were observed in all patients. On follow-up FDG PET/CT after appropriate therapy, FDG uptake and sizes of eschar, lymph nodes, and spleen were markedly decreased. As far as we are aware, this is the first investigation with multiple patients of FDG PET/CT in scrub typhus and the demonstration of clinical utility. FDG PET/CT imaging of scrub typhus could provide useful information about the clinical features before and after antibiotic treatment.
Databáze: OpenAIRE
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