Degenerative and regenerative processes involved in midgut pseudotumor formation in the stick insect (Carausius morosus)
Autor: | August Dorn, Matthias Holtmann, Paul Hoffmann |
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Rok vydání: | 2009 |
Předmět: |
Carausius morosus
Pathology medicine.medical_specialty Hemocytes Insecta Cellular differentiation Columnar Cell Granuloma Plasma Cell Digestive System Physiological Phenomena Stomatogastric nervous system medicine Animals Homeostasis Regeneration Progenitor cell Tissue homeostasis Cell Proliferation biology Stem Cells fungi Cell Differentiation Midgut biology.organism_classification stomatognathic diseases Animal Science and Zoology Stem cell Digestive System Developmental Biology |
Zdroj: | Journal of Morphology. 270:1454-1474 |
ISSN: | 1097-4687 0362-2525 |
DOI: | 10.1002/jmor.10770 |
Popis: | Spontaneous and experimentally induced pseudotumor formation in Carausius morosus impairs the midgut tissue homeostasis. Spontaneous pseudotumor formation begins by the break down of a single or a small group of columnar cells (CCs) and is followed by the degeneration of neighboring CCs. There are not only marked similarities but also decisive differences between normal dying CCs in healthy specimens and the degeneration of CCs leading to pseudotumors: in both cases, the apical cell parts with the nucleus are extruded into the midgut lumen, but only during of pseudotumor formation an "amorphous substance" originates from the basal parts of the CCs. Hemocytes are attracted to this substance and form a nodule-like aggregation, which is responsible for the phenotype of pseudotumors. Pseudotumor infestation has also an impact on the midgut nidi, which consist of an intestinal stem cell and several CC progenitor cells. In healthy specimens only one progenitor cell per nidus differentiates at a time, but, several to all progenitor cells differentiate simultaneously in pseudotumor-infested specimens. Extirpation of the ingluvial ganglion in healthy specimens results in an immediate onset of pseudotumor formation and a dramatic acceleration of pseudotumor growth. Importantly, the ultrastructural characteristics of spontaneous and experimentally induced pseudotumors are identical. This supports the idea that the stomatogastric nervous system plays an integral role in the maintenance of midgut tissue homeostasis. |
Databáze: | OpenAIRE |
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