The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD‑induced non‑alcoholic fatty liver in rats
| Autor: | Ahmed Sakr, Ahmed H.M. Ghobashi, Maher A. Kamel, Soha E.M. El‑Adely, Eman L.M. Zaher, Mervat Y. Hanafi, Madiha H. Hemly, Amani H. Kazem |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Glutathione reductase Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Immunology and Microbiology (miscellaneous) Internal medicine medicine Glucose homeostasis chemistry.chemical_classification medicine.diagnostic_test Glutathione peroxidase Fatty liver Articles General Medicine Glutathione medicine.disease 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis Liver function tests |
| Zdroj: | Experimental and Therapeutic Medicine. |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | The present study was designed to investigate the therapeutic effects of bee venom (BV) on high-fat diet (HFD)-induced non-alcoholic fatty liver (NAFL) in rats at different levels. Histological manifestations, hepatic lipid content, liver function tests, glucose homeostasis, lipid abnormalities, adipocytokines, lipid peroxidation, disturbed glutathione and antioxidant enzymes systems and dysregulation of Nrf2 transcription factor were assessed. In the present study, the NAFL rats were subcutaneously treated with BV with different doses (0.01, 0.05, 0.1 mg/kg). The results indicated that BV treatment completely normalized the lipid profile values of NAFL rats. Fasting blood sugar, insulin level and homeostatic model assessment of insulin resistance significantly decreased. BV treated rats showed a significantly lower level of all liver enzymes and bilirubin. Moreover, BV treatment significantly increased the levels of active nuclear erythroid factor 2 like 2, glutathione (GSH) (total and reduced), GSH/glutathione disulphide ratio and activities of glutathione reductase, glutathione-S-transferase and glutathione peroxidase (total and Se-dependent). The level of tumor necrosis factor-α was reduced. Treatment showed correction of adiponectin level, and significant downregulation of hepatic triglycerides and cholesterol. At the histological level, BV improved the architecture of liver cells showing normal sinusoids. It may be concluded that BV may represent an interesting therapeutic alternative for the treatment of NAFL disease. |
| Databáze: | OpenAIRE |
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