The biotransformation of some clovanes by botrytis cinerea
| Autor: | Isidro G. Collado, Daniel J. Mobbs, † and Antonio J. Macías-Sánchez, James R. Hanson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
biology Chemistry Stereochemistry Organic Chemistry Pharmaceutical Science Biological activity Fungus Fungi imperfecti biology.organism_classification Sesquiterpene Terpenoid Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine Biotransformation Drug Discovery Molecular Medicine Organic chemistry Epimer Botrytis cinerea |
| Zdroj: | Journal of natural products. 61(11) |
| ISSN: | 1520-6025 |
| Popis: | The metabolism of the fungistatic agent 2beta-methoxyclovan-9alpha-ol (2) by the fungus Botrytis cinerea has been investigated. Biotransformation of compound 2 yielded compounds 3-5, 7, and 9. The major metabolites of compound 2 each show much reduced biological activity when compared with the parent compound. Also studied were the effects of B. cinerea on the metabolism of the related compounds 2beta-methoxyclovan-9-one (3), 2beta-methoxyclovan-9beta-ol (4), and clovan-2,9-dione (6). Compounds 3, 4, 8, and 9 are described for the first time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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