Serum level of fetuin B is associated with osteoporosis: a 4-year prospective study in China
| Autor: | Zhong-Hua Zhou, Jin He, Xing Zhang, Hua Xie, Xiang Luo, Ya-Wen Sun, Zhong-Hua Xu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Bone density Osteoporosis Lumbar vertebrae Bone Density Internal medicine medicine Humans Prospective Studies Prospective cohort study Triglycerides Femoral neck Aged Bone mineral Aged 80 and over Lumbar Vertebrae business.industry Femur Neck Incidence (epidemiology) Incidence General Medicine Middle Aged medicine.disease Fetuin Fetuin-B medicine.anatomical_structure Endocrinology Female business Follow-Up Studies |
| Zdroj: | Clinical and investigative medicine. Medecine clinique et experimentale. 41(1) |
| ISSN: | 1488-2353 |
| Popis: | Purpose: As a novel hepatokine, fetuin B involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and liver via the secretion of hepatokines. The association between serum fetuin B and osteoporosis was evaluated in a 4-year hospital-based prospective study of 1,370 Chinese postmenopausal women. Methods: Bone mineral densities (BMDs) were obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry. Serum fetuin B level was tested by enzyme-linked immunosorbent assay. Results: Of the 1,370 participants in the baseline study (2012), 650 subjects were included in the 4-year follow-up study (2016). Serum fetuin B level presented higher in subjects with osteoporosis (106.7 ± 17.6 μg/ml) than it in controls (86.3 ± 17.5 μg/ml) (P < 0.001). Meanwhile, fetuin B positively correlated with triglycerides (r = 0.227, P = 0.001), femoral BMD (r = -0.426, P < 0.001) and lumbar BMD (r = -0.332, P < 0.001). At the 4-year follow-up, 116 subjects had developed osteoporosis. Serum fetuin B concentration was significantly higher in subjects who developed (P < 0.001). The osteoporosis incidence increased from Q1 9.9%, Q2 14.7%, and Q3 17.8% to Q4 30.2% (P for trend < 0.001), among the quartiles of baseline fetuin B. A higher fetuin B baseline level was linked to the incidence of osteoporosis (adjusted OR = 1.179, 95% CI [1.119 – 1.243], P = 0.009). Conclusion: Serum fetuin B levels increased with the development of osteoporosis. |
| Databáze: | OpenAIRE |
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