Impact of Visceral Obesity and Sarcopenia on Short-Term Outcomes After Colorectal Cancer Surgery

Autor: Zhen Yu, Cheng-Le Zhuang, Feng-Min Zhang, Xiao-Xi Chen, Xiao-Dong Chen, Xiao-Lei Chen, Wei-Zhe Chen, Ji Lin, Liang-Liang Ma
Rok vydání: 2018
Předmět:
Male
Sarcopenia
Time Factors
Multivariate analysis
Physiology
Colorectal cancer
Comorbidity
Postoperative Complications
0302 clinical medicine
Risk Factors
Odds Ratio
Prevalence
Medicine
Prospective Studies
Hospital Costs
Prospective cohort study
Colectomy
Aged
80 and over
Incidence
Incidence (epidemiology)
Age Factors
Gastroenterology
Middle Aged
musculoskeletal system
Treatment Outcome
Obesity
Abdominal
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Colorectal Neoplasms
China
medicine.medical_specialty
Protective factor
03 medical and health sciences
Internal medicine
Humans
Aged
Proportional Hazards Models
Chi-Square Distribution
business.industry
Length of Stay
Protective Factors
Hepatology
medicine.disease
Obesity
body regions
Logistic Models
Multivariate Analysis
Laparoscopy
business
human activities
Zdroj: Digestive Diseases and Sciences. 63:1620-1630
ISSN: 1573-2568
0163-2116
Popis: With the increased prevalence of obesity and sarcopenia, those patients with both visceral obesity and sarcopenia were at higher risk of adverse outcomes. The aim of this study was to ascertain the combined impact of visceral obesity and sarcopenia on short-term outcomes in patients undergoing colorectal cancer surgery. We conducted a prospective study from July 2014 to February 2017. Patients’ demographic, clinical characteristics, physical performance, and postoperative short-term outcomes were collected. Patients were classified into four groups according to the presence of sarcopenia or visceral obesity. Clinical variables were compared. Univariate and multivariate analyses evaluating the risk factors for postoperative complications were performed. A total of 376 patients were included; 50.8 and 24.5% of the patients were identified as having “visceral obesity” and “sarcopenia,” respectively. Patients with sarcopenia and visceral obesity had the highest incidence of total, surgical, and medical complications. Patients with sarcopenia or/and visceral obesity all had longer hospital stays and higher hospitalization costs. Age ≥ 65 years, visceral obesity, and sarcopenia were independent risk factors for total complications. Rectal cancer and visceral obesity were independent risk factors for surgical complications. Age ≥ 65 years and sarcopenia were independent risk factors for medical complications. Laparoscopy-assisted operation was a protective factor for total and medical complications. Patients with both visceral obesity and sarcopenia had a higher complication rate after colorectal cancer surgery. Age ≥ 65 years, visceral obesity, and sarcopenia were independent risk factors for total complications. Laparoscopy-assisted operation was a protective factor.
Databáze: OpenAIRE
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