The Significance of Thrombocytosis in Patients with Locally Advanced Cervical Carcinoma: A Gynecologic Oncology Group Study
| Autor: | Paul B. Heller, Kathleen A. Donohue, Enrique Hernandez, Frederick B. Stehman, Lisa Anderson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Radiation-Sensitizing Agents medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Antineoplastic Agents Gynecologic oncology Gastroenterology Disease-Free Survival Cohort Studies Internal medicine Carcinoma Humans Hydroxyurea Multicenter Studies as Topic Medicine Misonidazole Survival analysis Aged Proportional Hazards Models Randomized Controlled Trials as Topic Thrombocytosis business.industry Proportional hazards model Incidence Incidence (epidemiology) Obstetrics and Gynecology Middle Aged medicine.disease Combined Modality Therapy Survival Analysis Surgery Radiation therapy Oncology Relative risk Lymph Node Excision Female Neoplasm Recurrence Local business |
| Zdroj: | Gynecologic Oncology. 78:137-142 |
| ISSN: | 0090-8258 |
| DOI: | 10.1006/gyno.2000.5838 |
| Popis: | Objective. The aim of this study was to determine the incidence of thrombocytosis and its possible impact on survival probability among women with locally advanced cervical carcinoma. Methods. The database of 294 patients with Stages IIB–IVA cervical carcinoma without periaortic node metastasis who were treated with standardized radiation therapy and concurrent hydroxyurea or misonidazole was analyzed. Pretreatment platelet counts were available for 291 patients who are the subject of this study. Results. Thrombocytosis (platelet count >400 × 10 9 /liter) was present in 86 (29.6%) of the 291 patients. A multivariate Cox proportional hazards model showed that patients without extrapelvic disease and with thrombocytosis had a 55% greater chance of dying than those without thrombocytosis (relative risk=1.55, 95% confidence interval 1.08–2.21). Patients with thrombocytosis had larger tumors and more frequently had bilateral parametrial involvement, tumor fixation to the sidewall, and positive pelvic lymph nodes than patients without thrombocytosis. Thrombocytosis was not found to be a prognostic factor in patients with positive pelvic nodes. However, in patients with negative pelvic nodes, the presence or absence of thrombocytosis was related to survival. Conclusion. Thrombocytosis is a frequent finding among patients with advanced cervical carcinoma and seems to be related to tumor burden. Among patients with locally advanced cervical carcinoma who had negative pelvic nodes, those with thrombocytosis had a poorer survival. |
| Databáze: | OpenAIRE |
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