The use of single-pill combinations as first-line treatment for hypertension: translating guidelines into clinical practice
| Autor: | Elke Lehmann, Erika Maria Gonçalves Campana, A. Vintila, Min Zaw Oo, Guillaume Lamirault, Sigita Glaveckaite, Krzysztof Narkiewicz, Stéphane Laurent, A. Vachulova, Vitória Cunha, Liliane Mfeukeu Kuate, Ivan Gruev, Larysa Mishshenko, Jacek Wolf, Stefano Masi, Nadezhda Zvartau, Oana Tautu, Deborah Ignacia D. Ona |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry Cardiology MEDLINE Blood Pressure 030204 cardiovascular system & hematology Clinical Practice First line treatment Drug Combinations 03 medical and health sciences 0302 clinical medicine Blood pressure Pill Hypertension Practice Guidelines as Topic Internal Medicine Humans Medicine 030212 general & internal medicine Medical prescription Cardiology and Cardiovascular Medicine business Intensive care medicine Antihypertensive Agents |
| Popis: | The 2008 European Society of Cardiology/European Society of Hypertension guidelines recommend the first-line prescription of two antihypertensive drugs in single-pill combinations (SPCs), also known as fixed-dose combinations, for the treatment of most patients with hypertension. This recommendation is based on a large amount of data, which shows that first-line treatment with SPCs supports reaching blood pressure targets rapidly and reducing cardiovascular outcome risk while keeping the therapeutic strategies as simple as possible and fostering adherence and persistence. As this approach constitutes a big shift from the stepped-care approaches that have been dominant for many years, practicing physicians have expressed concerns about using SPCs as first-line agents. In this review, we will discuss the barriers to the uptake of this recommendation. We will also offer suggestions to reduce the impact of these barriers and address specific concerns that have been raised. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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