Multicenter reperfusion trial of intravenous anisoylated plasminogen streptokinase activator complex (APSAC) in acute myocardial infarction: Controlled comparison with intracoronary streptokinase
| Autor: | Ronald L. Menlove, Charles F. Dahl, Gary P. Symkoviak, Jeffrey L. Anderson, Robert L. Rothbard, Sherman G. Sorensen, Arthur D. Hagan, Harry W. Eckerson, Patricia G. Fitzpatrick, Rosemary A. Hackworthy, Kevin F. Browne, Victor J. Marder, William H. Barry |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Streptokinase medicine.medical_treatment Myocardial Infarction Hemorrhage Random Allocation Fibrinolytic Agents Recurrence Coronary Circulation Internal medicine medicine Humans Myocardial infarction Blood Coagulation Vascular Patency Aged Clinical Trials as Topic Catheter insertion Anistreplase business.industry Plasminogen Middle Aged medicine.disease Surgery Coronary occlusion Intravenous therapy Injections Intravenous Cardiology Female Cardiology and Cardiovascular Medicine business Plasminogen activator Fibrinolytic agent medicine.drug |
| Zdroj: | Journal of the American College of Cardiology. (6):1153-1163 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/0735-1097(88)90276-8 |
| Popis: | The recent establishment of a firm therapeutic role for reperfusion in acute myocardial infarction has stimulated interest in the development of more ideal thrombolylic agents. Anisoylated plasminogen streptokinase activator complex (APSAC) is a new plasminogen activator possessing properties that are promising for intravenous thrombolytic application in acute myocardial infarction. To assess the reperfusion potential of intravenous APSAC, a multicenter, angiographically controlled reperfusion trial was performed. An approved thrombolytic regimen of intracoronary streptokinase served as a control. Consen patients with clinical and electrocardiographic signs of acute myocardial infarction were studied angiographically and 240 qualifying patients with documented coronary occlusion (flow grade 0 or 1) were randomized to treatment in |
| Databáze: | OpenAIRE |
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